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Aspirin Safety News

Study finds aspirin may be linked to breast cancer risk

June 1, 2005

Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin and ibuprofen, might increase the risk of breast cancer, according to a study published in the latest issue of the Journal of the National Cancer Institute .

The study is the first one to suggest that NSAID use might increase the risk of breast cancer, finding the daily use of aspirin increases risk of estrogen receptor/progesterone receptor (ER/PR)- negative breast tumor, while prolonged daily use of ibuprofen increases the risk of non-localized breast cancer.

Lead author of the study, Sarah Marshall, said the researchers were expecting ibuprofen and aspirin to reduce risk of breast cancer, as earlier studies suggested they might. Instead, after tracking the health of 114,460 women aged between 22 and 85 years, who were healthy when they joined the study in 1995 and 1996, included 2,391 women diagnosed with breast cancer in the next six years.

Regular use of aspirin and ibuprofen - characterized by more than once a week - had no collective link to breast cancer, but when the findings were broken up according to the type of pain reliever and type of breast cancer, researchers found that women taking ibuprofen daily for a period of at least five years had 50 percent higher chances of breast cancer than those who did not. Additionally, women taking aspirin on a daily basis for at least five years - and not sensitive to estrogen or progesterone - had 80 percent greater chances of breast cancer than women who were not regular aspirin users.

Some experts are skeptical about the latest findings, but acknowledge there must be more studies to better ascertain the risks.

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