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Cyclosporine and citrus soda cause adverse reactions
-April 16, 2004
A double lung transplant patient suffering abnormal blood chemistries during post-transplant check ups discovered a link between citrus soda and its effect on cyclosporine. The patient's transplant had been successful, as well as his post-operative recovery so it was a medical mystery when his lab tests revealed his cyclosporine serum levels were elevated to more than double the suggested concentration, causing high risk for drug toxicity and other very serious adverse effects.
High levels of cyclosporine could potentially cause kidney damage or central nervous system damage for the patient, yet no one knew why this occurrence was happening. After failing to identify a reason for the high cyclosporine levels, the patient began to closely examine his diet. Since all transplant patients are told to avoid grapefruit or Mediterranean orange consumption, the patient thought his consumption of Sun Drop, a popular citrus soda may be a contributor to his high cyclosporine levels.
A team of medical detectives followed up with finding out the contents of Sun Drop, soon finding out the citrus drink did contain grapefruit juice. Now, a formal study will be performed to determine the extent of citrus drink effects on the excretion and absorption of cyclosporine, as well as other prescription drugs.
For more information on cyclosporine, please contact us.
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