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Bextra may have higher risk of stroke and heart attack
-October 18, 2004
Pfizer, Inc. announced two small clinical trials showed that heart bypass surgery patients taking its anti-inflammatory drug Bextra had a higher risk of stroke and heart attack. Bextra is a COX-2 inhibitor drug, part of the same class of drug as Merck & Co.'s recently recalled arthritis and pain relief drug Vioxx. Following the Vioxx recall, experts quickly warned that the increased risk of cardiovascular events may be a class - wide effect, bringing closer scrutiny on the two remaining COX-2 inhibitors on the market, Pfizer's Bextra and Celebrex.
Pfizer has also said it is updating Bextra labeling to reflect a stronger warning about a rare but serious skin reaction that can occur mainly in the first two weeks of drug therapy.
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